Vaxxinity
PUBLICATIONS

Safety, tolerability, immunogenicity, and efficacy of UB-311 in participants with mild Alzheimer's disease: a randomised, double-blind, placebo-controlled, phase 2a study

HuiJing Yu, Samuel P. Dickson, Pei-Ning Wang, Ming-Jang Chiu, Chin-Chang Huang, Chiung-Chih Chang, Hope Liu, Suzanne B. Hendrix, Jean-Cosme Dodart, Ajay Verma, Chang Yi Wang, Jeffrey Cummings

The Lancet eBioMedicine

2023 June 29; doi: https://doi.org/10.1016/j.ebiom.2023.104665.

A Randomized First-in-Human Study With UB-312, a UBITh® α-Synuclein Peptide Vaccine

Yu HJ, Thijssen E, van Brummelen E, et al.

Movement Disorders Society Journal

2022 Apr 15; doi:10.1002/mds.29016

Immunisation with UB-312 in the Thy1SNCA mouse prevents motor performance deficits and oligomeric α-synuclein accumulation in the brain and gut.

Nimmo JT, Smith H, Wang CY, Teeling JL, Nicoll JAR, Verma A, Dodart JC, Liu Z, Lin F, Carare RO

Acta Neuropathologica

2022 Jan;143(1):55-73. doi: 10.1007/s00401-021-02381-5

Novel antibodies detect additional α-synuclein pathology in synucleinopathies: potential development for immunotherapy.

Nimmo JT, Verma A, Dodart JC, Wang CY, Savistchenko J, Melki R, Carare RO, Nicoll JAR

Alzheimer's Research & Therapy

2020 Nov 30;12(1):159. doi: 10.1186/s13195-020-00727-x

VXX-401, a novel anti-PCSK9 vaccine, reduces LDL-C in cynomolgus monkeys

Madeline M. Vroom, Hanxin Lu, Maggie Lewis, Brett A. Thibodeaux, Jeanne K. Brooks, Matthew S. Longo, Martina M. Ramos, Jaya Sahni, Jonathan Wiggins, Justin D. Boyd, Shixia Wang, Shuang Ding, Michael Hellerstein, Valorie Ryan, Peter Powchik, Jean-Cosme Dodart

Journal of Lipid Research

2024 Feb; doi.org/10.1016/j.jlr.2024.100497

RBD-Protein/Peptide Vaccine UB-612 Elicits Mucosal and Fc-Mediated Antibody Responses against SARS-CoV-2 in Cynomolgus Macaques

Shixia Wang , Farshad Guirakhoo , Sivakumar Periasamy , Valorie Ryan, Jonathan Wiggins, Chandru Subramani, Brett Thibodeaux, Jaya Sahni, Michael Hellerstein, Natalia A. Kuzmina, Alexander Bukreyev, Jean-Cosme Dodart and Alexander Rumyantsev.

Vaccines

2023 Nov 20; 12(1), 40; doi: 10.3390/vaccines12010040

High neutralizing antibody levels against SARS-CoV-2 Omicron BA.1 and BA.2 after UB-612 vaccine booster

Farshad Guirakhoo, Shixia Wang, Chang Yi Wang, Hui Kai Kuo, Wen Jiun Peng, Hope Liu, Lixia Wang, Marina Johnson, Adam Hunt, Mei Mei Hu, Thomas P Monath, Alexander Rumyantsev, David Goldblatt

The Journal of Infectious Diseases

2022 Jun 20; doi.org/10.1093/infdis/jiac241

A novel RBD-protein/peptide vaccine elicits broadly neutralizing antibodies and protects mice and macaques against SARS-CoV-2

Shixia Wang, Chang Yi Wang, Hui-Kai Kuo, Wen-Jiun Peng, Juin-Hua Huang, Be-Shen Kuo, Feng Lin, Yaw-Jen Liu, Zhi Liu, Huang-Ting Wu, Shuang Ding, Kou-Liang Hou, Jennifer Cheng, Ya-Ting Yang, Ming-Han Jiang, Min-Sheng Wang, Tony Chen, Wei Guo Xia, Ed Lin, Chung Ho Hung, Hui-Jung Chen, Zhonghao Shih, Yi Ling Lin, Valorie Ryan, Mei Mei Hu, D. Gray Heppner, Delphine C. Malherbe, Sivakumar Periasamy, Natalia Kuzmina, Chandru Subramani, Michael Hellerstein, Thomas P. Monath, Alexander Rumyantsev, Alexander Bukreyev & Farshad Guirakhoo

Emerging Microbes & Infections

2022 Nov 11; DOI: 10.1080/22221751.2022.2140608

High neutralizing antibody levels against SARS-CoV-2 Omicron after UB-612 booster vaccination

Farshad Guirakhoo, Shixia Wang, Chang Yi Wang, Hui-Kai Kuo, Wen-Jiun Peng, Hope Liu, Lixia Wang, Marina Johnson, Adam Hunt, Mei Mei Hu, Thomas P Monath, Alexander Rumyantsev, David Goldblatt

The Journal of Infectious Diseases

2022 Mar 21; doi.org/10.1101/2022.03.18.484436

Potent Anti-Delta Effect By a Booster Third-Dose of UB-612, a Precision-Designed SARS-CoV-2 Multitope Protein-Peptide Vaccine

Chang Yi wang, Kao-Pin Hwang, Hui-Kai Kuo, James Peng, Daphne Shen, Besheng Kuo, Kuo-Liang Hou, Jennifer Cheng, Min-Sheng Wang, Ya-Ting Yang, Juin-Hua Huang, Han Chen Chiu, Ming-Han Jiang, Hao-Yu Shih, Hsuan-Yu Shen, Po-Yen Chang, Yu-Rou Lan, Sky Chen, Hope Liu, Yu-Hsin Ho, Feng Lin, Shuang Ding, Zhi Liu, Huang-Ting Wu, Yi-Ling Lin, Jian-Jong Liang, Chun-Che Liao, Yu-Chi Chou, Mary Kate Morris, Carl Hanson, Farshad Guirakhoo, Michael Hellerstein, Mei Mei Hu, Hui-Jiing Yu, Chwan-Chuen King King, Donald Heppner, Tracy Kemp, Tom Monath

Research Square

2021 Oct 18; DOI: 10.21203/rs.3.rs-944205/v1

A Novel SARS-CoV-2 Multitope Protein/Peptide Vaccine Candidate is Highly Immunogenic and Prevents Lung Infection in an Adeno Associated Virus Human Angiotensin-Converting Enzyme 2 (AAV hACE2) Mouse Model

Farshad Guirakhoo, Lucy Kuo, James Peng, Juin Hua Huang, Ben Kuo, Feng Lin, Kevin Liu, Zhi Liu, Grace Wu, Shuang Ding, Lou-Liang Hou, Jennifer Cheng, Vicky Yang, Hank Jiang, Jason Wang, Tony Chen, WeiGuo Xia, Ed Lin, Chung Ho Hung, Kate Chen, Zhonghao Shih, Yilin Lin, Brandon T. Schurter, Mei Mei Hu, Gray Heppner, Delphine C. Malherbe, Alexander Bukreyev, Michael Hellerstein, Thomas Monath, Chang Yi Wang

bioRxiv

2020 Nov 30; doi.org/10.1101/2020.11.30.399154

UB-311, a novel UBITh® amyloid β peptide vaccine for mild Alzheimer's disease.

Chang Yi Wang, Pei-Ning Wang, Ming-Jang Chiu,Connie L. Finstad, Feng Lin, Shugene Lynn, Yuan-Hung Tai, Xin De Fang,a Kesheng Zhao, Chung-Ho Hung, Yiting Tseng, Wen-Jiun Peng, Jason Wang, Chih-Chieh Yu, Be-Sheng Kuo, and Paul A. Frohnac

Alzheimer’s & Dementia

2017 Jun; 3(2): 262–272. doi: 10.1016/j.trci.2017.03.005

Site-specific UBITh amyloid-beta vaccine for immunotherapy of Alzheimer's disease.

Chang Yi Wang, Connie L Finstad, Alan M Walfield, Charles Sia, Kenneth K Sokoll, Tseng-Yuan Chang, Xin De Fang, Chung Ho Hung, Birgit Hutter-Paier, Manfred Windisch

Vaccine

2007 Apr 20;25(16):3041-52. doi: 10.1016/j.vaccine.2007.01.031. Epub 2007 Jan 19

Site-specific peptide vaccines for immunotherapy and immunization against chronic diseases, cancer, infectious diseases, and for veterinary applications

Chang Yi Wang , Alan M Walfield

Vaccine

2005 Mar 18;23(17-18):2049-56. doi: 10.1016/j.vaccine.2005.01.007.